Home
Products
Ilexsaponin A
| Product Name | Ilexsaponin A |
| Price: | $219 / 20mg |
| Catalog No.: | CN07375 |
| CAS No.: | 108524-93-2 |
| Molecular Formula: | C36H56O11 |
| Molecular Weight: | 664.83 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The roots of Ilex pubescens Hook. et Arn. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OC[C@H]1O[C@@H](OC(=O)[C@@]23CC[C@H]([C@@]([C@H]3C3=CC[C@H]4[C@@]([C@@]3(CC2)C)(C)CC[C@@H]2[C@]4(C)CC[C@@H]([C@]2(C)C(=O)O)O)(C)O)C)[C@@H]([C@H]([C@@H]1O)O)O |
| Contact us | |
|---|---|
| First Name: | |
| Last Name: | |
| E-mail: | |
| Question: | |
| Description | Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes[1]. |
| In Vitro | Ilexsaponin A significantly reduces proapoptotic proteins including caspase-3, cleaved caspase-3 and bax and increases anti-apoptotic protein bcl-2 in hypoxia/reoxygenation cardiomyocytes. Ilexsaponin A treatment increases the expression levels of p-Akt in hypoxia/reoxygenation cellular model and myocardial ischemia/reperfusion animal model[1]. |
| In Vivo | Ilexsaponin A (10 or 40 mg/kg) reduce the myocardial infarct size in a dose dependent manner in male Sprague-Dawley rats weighing 280-320 g[1]. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 788.1±60.0 °C at 760 mmHg |
| Flash Point | 240.1±26.4 °C |
| Exact Mass | 664.382263 |
| LogP | 5.11 |
| Vapour Pressure | 0.0±6.2 mmHg at 25°C |
| Storage condition | 2-8℃ |