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LDC000067
| Product Name | LDC000067 |
| Price: | Inquiry |
| Catalog No.: | CN00485 |
| CAS No.: | 1073485-20-7 |
| Molecular Formula: | C18H18N4O3S |
| Molecular Weight: | 370.43 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1ccccc1c1ncnc(c1)Nc1cccc(c1)CS(=O)(=O)N |
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| Description | LDC000067 is a highly specific CDK9 inhibitor with an IC50 value of 44±10 nM in vitro. |
| Target | CDK9- Cyclin T1:44 nM (IC50) cdk2-cyclin A:2441 nM (IC50) cdk1-cyclin B1:5513 nM (IC50) cdk4-cyclin D1:9242 nM (IC50) GSK3A:1460 nM (IC50) HGK/MAP4K4:820 nM (IC50) ABL2/ARG:3640 nM (IC50) |
| In Vitro | The selectivity of LDC000067 for CDK9 over other CDKs exceeds that of the known inhibitors flavopiridol and DRB. LDC000067 displayed 55/125/210/ >227/ >227-fold selectivity for CDK9 versus CDK2/1/4/6/7. LDC000067 inhibits in vitro transcription in an ATP-competitive and dose-dependent manner. Gene expression profiling of cells treated with LDC000067 demonstrates a selective reduction of short-lived mRNAs, including important regulators of proliferation and apoptosis[1]. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 604.1±65.0 °C at 760 mmHg |
| Flash Point | 319.2±34.3 °C |
| Exact Mass | 370.109955 |
| PSA | 115.58000 |
| LogP | 2.11 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Storage condition | -20℃ |