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Lupiwighteone
| Product Name | Lupiwighteone |
| Price: | Inquiry |
| Catalog No.: | CN04868 |
| CAS No.: | 104691-86-3 |
| Molecular Formula: | C20H18O5 |
| Molecular Weight: | 338.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The roots of Glycyrrhiza glabra |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Lupiwighteone is an isoflavone present widely in wild-growing plants, with antioxidant, antimicrobial and anticancer effects. Lupiwighteone induces caspase-dependent and -independent apoptosis on human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway[1][2]. |
| Target | apoptosis[2] |
| In Vitro | Lupiwighteone (2-100 μM; 72 hours) shows cytotoxicity towards various cell lines, especially on DU-145 cells and SGC-7901 cells with IC50s of 23.7 μM and 21 μM, respectively[2]. Lupiwighteone (20-60 μM; 48 hours) induces (cell cycle arrest in DU-145 cells[2]. Lupiwighteone (20-60 μM; 48 hours) induces cells apoptosis[2]. Lupiwighteone (20-60 μM; 48 hours) decreases the cell cycle-related protein expressions in a dose-dependent manner in DU-145 cells[2]. Lupiwighteone (20-60 μM; 48 hours) induces a dose-dependent increase in ROS production[2]. Lupiwighteone up-regulates of cytochrome c and caspase-3, and subsequent cleavage of PARP-1 and down-regulates of the p-Akt/Akt ratio and VEGF expression, suggests the activation of mitochondria-based intrinsic apoptosis in DU-145 cells[2]. Cell Viability Assay[2] Cell Line: DU-145 cells, C4-2 cells, SGC-7901 cells, Hela cells, HUVEC, MCF-7 cells, CNE cells, Vero Concentration: 2 μM, 5 μM, 25 μM, 50 μM, 100 μM Incubation Time: 72 hours Result: Had inhibition on the survival of many cancer cell lines and HUVEC. Cell Cycle Analysis[2] Cell Line: DU-145 cells Concentration: 20 μM, 40 μM, 60 μM Incubation Time: 48 hours Result: Induced cell cycle arrest. Apoptosis Analysis[2] Cell Line: DU-145 cells Concentration: 20 μM, 40 μM, 60 μM Incubation Time: 48 hours Result: Induced apoptosis. Western Blot Analysis[2] Cell Line: DU-145 cells Concentration: 20 μM, 40 μM, 60 μM Incubation Time: 48 hours Result: Decreased CDK1, 2, 4, 6, cyclinD1, and cyclinB1 protein expression in a dose-dependent manner. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 583.5±50.0 °C at 760 mmHg |
| Flash Point | 211.8±23.6 °C |
| Exact Mass | 338.115417 |
| PSA | 90.90000 |
| LogP | 5.05 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |