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Tussilagone
| Product Name | Tussilagone |
| Price: | $77 / 20mg |
| Catalog No.: | CN09291 |
| CAS No.: | 104012-37-5 |
| Molecular Formula: | C23H34O5 |
| Molecular Weight: | 390.51 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The flowers of Tussilago farfara. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CCC(=CC(=O)OC1CC(C(C)C)C2C(C1=C)CC(=O)C2C(OC(=O)C)C)C |
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| Description | Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice[1][2]. |
| In Vitro | Tussilagone suppressed the expression of the inflammatory mediators, nitric oxide and prostaglandin E2, and the inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and high-mobility group box 1 (HMGB1), in lipopolysaccharide-stimulated RAW 264.7 cells and peritoneal macrophages. Tussilagone also reduced the activation of the mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) involved in the activation of various inflammatory mediators in activated macrophages[1]. |
| In Vivo | Tussilagone administration (1 mg/kg and 10 mg/kg) produced decreased mortality and lung injury in CLP-activated septic mice. Augmented expression of cyclooxygenase (COX)-2 and TNF-α in pulmonary alveolar macrophages of septic mice were attenuated by tussilagone administration[2]. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 471.3±35.0 °C at 760 mmHg |
| Flash Point | 200.7±26.0 °C |
| Exact Mass | 390.240631 |
| PSA | 69.67000 |
| LogP | 5.03 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Storage condition | -20°C |