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Glibenclamide
| Product Name | Glibenclamide |
| Price: | Inquiry |
| Catalog No.: | CN00795 |
| CAS No.: | 10238-21-8 |
| Molecular Formula: | C23H28ClN3O5S |
| Molecular Weight: | 494.00 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1ccc(cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1)Cl |
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| Description | Glibenclamide(Glyburide) is a sulfonylurea compound that modulates insulin production. IC50 value:Target:Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glibenclamide, a sulphonylurea oral hypoglycaemic agent is a widely used antagonist of cromakalim-activated K+ channels in smooth muscle. Binding of Gli to SUR produces the closure of KATP channels and the inhibition of their activity. Glibenclamide is widely used for treatment of type 2-diabetes and it has been signaled as antiproliferative in several tumor cell lines. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 705.7±70.0 °C at 760 mmHg |
| Flash Point | 380.6±35.7 °C |
| Exact Mass | 493.143829 |
| PSA | 121.98000 |
| LogP | 5.19 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |