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Isoprocurcumenol
| Product Name | Isoprocurcumenol |
| Price: | Inquiry |
| Catalog No.: | CN09312 |
| CAS No.: | 102130-90-5 |
| Molecular Formula: | C15H22O2 |
| Molecular Weight: | 234.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Oil |
| Source: | The rhizomes of Curcuma phaeocaulis. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and Akt. Isoprocurcumenol promotes the proliferation of keratinocytes[1][2][3]. |
| Target | ERK Akt |
| In Vitro | Isoprocurcumenol (10 μM, 0-1 h) 可促进 ERK 和 AKT 的磷酸化[3]。 Isoprocurcumenol (0-200 μM, 24 or 48 h) 诱导角质形成细胞 HaCaT 细胞增殖[3]。 Isoprocurcumenol (1 μM, 1 h) 通过激活 EGFR 信号通路增加细胞生长和增殖相关基因的表达，例如 c-fos、c-jun、c-myc 和 egr-1[ 3]。 Isoprocurcumenol 诱导细胞恢复和伤口愈合[3]。 Western Blot Analysis[3] Cell Line: HaCaT cells (human keratinocyte cell) Concentration: 10 μM Incubation Time: 10, 30, or 60 min Result: Induced the phosphorylation of ERK and AKT after 10 min and this was sustained for 1 h. Cell Proliferation Assay[3] Cell Line: HaCaT cells (human keratinocyte cell) Concentration: 0 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 25 μM, 50 μM, 100 μM, or 200 μM Incubation Time: 24 or 48 h Result: Showed a significant increase in the proliferation of cells at most of the Isoprocurcumenol concentrations, starting at 10 nM. RT-PCR[3] Cell Line: HaCaT cells (human keratinocyte cell) Concentration: 1 μM Incubation Time: 1 h Result: Increased the expression of genes related to cell growth and proliferation, such as c-myc, c-jun, c-fos, and egr-1. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 360.3±41.0 °C at 760 mmHg |
| Flash Point | 153.7±20.2 °C |
| Exact Mass | 234.161987 |
| LogP | 2.59 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |