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Protosappanin A
| Product Name | Protosappanin A |
| Price: | Inquiry |
| Catalog No.: | CN03604 |
| CAS No.: | 102036-28-2 |
| Molecular Formula: | C15H12O5 |
| Molecular Weight: | 272.25 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The herbs of Caesalpinia sappan L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3[1]. |
| Target | JAK2 STAT3 |
| In Vitro | Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) significantly inhibits the production of TNF-α and IL-1β in LPS-activated BV2 microglia. And the mRNA expressions of IL-6, IL-1β, and MCP-1 are reduced by PTA in a dose-dependent manner in BV2 microglial cell line[1]. Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3, as well as STAT3 nuclear translocation against LPS treatment[1]. Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) shows obvious effect on disturbing the interaction of transmembrane protein CD14 with Toll-like receptor-4, resulting in the inhibition of NF-κB-dependent oxidative and nitrative stress in LPS-induced BV2 microglia[2]. Western Blot Analysis[1] Cell Line: Murine BV2 microglial cell line. Concentration: 12.5, 25, 50 μM. Incubation Time: 24 hours. Result: Inhibits the releases of NO, TNF-α and IL-1β in LPS-induced BV2 cells. Attenuated IL-6, IL-1β and MCP-1 gene expressions in the LPS-induced BV2 cells. Suppressed JAK2/STAT3 pathway activation in the LPS-induced BV2 cells. |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 613.1±55.0 °C at 760 mmHg |
| Flash Point | 238.8±25.0 °C |
| Exact Mass | 272.068481 |
| PSA | 86.99000 |
| LogP | 1.20 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |