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Kushenol K
| Product Name | Kushenol K |
| Price: | Inquiry |
| Catalog No.: | CN05024 |
| CAS No.: | 101236-49-1 |
| Molecular Formula: | C26H32O8 |
| Molecular Weight: | 472.5 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The roots of Sophora flavescens Ait. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3]. |
| Target | HSV-2:147 μM (EC50) CYP3A4:1.35 μM (Ki) SGLT |
| In Vitro | When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC50 values of 1.62 µM[1]. At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%[3]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 722.4±60.0 °C at 760 mmHg |
| Flash Point | 242.4±26.4 °C |
| Exact Mass | 472.209717 |
| LogP | 3.81 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |